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Vasoactive intestinal peptide affects the GABAergic system in the hypothalamic-pituitary axis.

作者信息

Duvilanski B H, Lasaga M, Seilicovich A, Afione S, Díaz M C, Debeljuk L

机构信息

Centro de Investigaciones en Reproducción, Facultad de Medicina, Universidad de Buenos Aires, Argentina.

出版信息

Brain Res Bull. 1990 Aug;25(2):215-9. doi: 10.1016/0361-9230(90)90063-6.

DOI:10.1016/0361-9230(90)90063-6
PMID:2224536
Abstract

The effect of a specific antiserum against vasoactive intestinal peptide (VIP) on GABA in the hypothalamic-pituitary axis was studied. The administration of anti-VIP serum (A-VIP) increased anterior pituitary GABA concentration in control rats, but decreased this neurotransmitter in rats with hyperprolactinemia induced by acute or chronic treatments with estrogens, or by the implanting of anterior pituitary glands under the kidney capsule. Besides, the injection of the A-VIP serum in the morning in proestrous rats causes a decrease in anterior pituitary GABA concentration, measured in the afternoon of the same day. The in vitro effect of A-VIP and VIP on endogenous GABA release from hypothalamic fragments and on anterior pituitary GABA concentration was studied. A-VIP increased both basal and high K(+)-evoked GABA effluxes whereas VIP produced a decrease in evoked GABA efflux from hypothalamic fragments. Furthermore, A-VIP inhibited the normal degradation of GABA that occurs in the isolated gland whereas VIP increased it. These results suggest that VIP modifies hypothalamic GABA release and anterior pituitary GABA concentration.

摘要

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引用本文的文献

1
Vasoactive intestinal peptide (VIP) mediates the effect of estrogens on the dopaminergic tone in the hypothalamic-pituitary axis of ovariectomized (OVX) rats.血管活性肠肽（VIP）介导雌激素对去卵巢（OVX）大鼠下丘脑-垂体轴中多巴胺能张力的影响。
Endocrine. 1997 Feb;6(1):53-6. doi: 10.1007/BF02738802.