Ichikawa Mizuho, Suzuki Daisuke, Inamoto Jun, Ohshima Junjiro, Cho Yuko, Saitoh Shinji, Kaneda Makoto, Iguchi Akihiro, Ariga Tadashi
Department of Pediatrics, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
J Pediatr Hematol Oncol. 2012 Apr;34(3):239-41. doi: 10.1097/MPH.0b013e3182352cf5.
Peripheral neuropathy is a well-known side effect of vincristine (VCR), a microtubule inhibitor commonly used to treat malignancies. Severe neurological adverse events can occur in patients with Charcot-Marie-Tooth disease (CMT) treated with VCR. Vindesine is also a microtubule inhibitor, which, like VCR, is widely used to treat malignancies. The case of an 11-year-old female patient with CMT type 1A who developed severe peripheral neuropathy induced by VCR given for her acute lymphoblastic leukemia is reported. Alternative treatment containing vindesine instead of VCR led to a successful outcome without a relapse of leukemia or neurological worsening of CMT.
周围神经病变是长春新碱（VCR）众所周知的副作用，VCR是一种常用于治疗恶性肿瘤的微管抑制剂。患有遗传性运动感觉神经病（CMT）的患者在接受VCR治疗时可能会发生严重的神经不良事件。长春地辛也是一种微管抑制剂，与VCR一样，广泛用于治疗恶性肿瘤。本文报告了一名11岁1A型CMT女性患者的病例，该患者因急性淋巴细胞白血病接受VCR治疗后发生严重周围神经病变。用长春地辛替代VCR的替代治疗取得了成功，白血病未复发，CMT的神经功能也未恶化。
