Woude Priscilla A Zetstra-van der, Walle Hermien E K de, Berg Lolkje T W de Jong-van den
Unit of Pharmacoepidemiology and Pharmacoeconomy, Department of Pharmacy, University of Groningen, Groningen, the Netherlands.
Birth Defects Res A Clin Mol Teratol. 2012 Feb;94(2):96-101. doi: 10.1002/bdra.22882. Epub 2012 Jan 13.
Folic acid use before and during pregnancy prevents neural tube defects. Since 1995, six surveys have been carried out among pregnant women to measure their knowledge and use of folic acid. The results of the most recent survey in 2009 will be discussed and compared with earlier surveys.
Pregnant women in the Northern Netherlands were asked to fill out a questionnaire when visiting their midwife or gynecologist.
Of the 515 participating women, 87.0% knew of folic acid before they became pregnant. Of all respondents, 51.6% reported to have used folic acid during the entire recommended period. Multivariate analysis showed that planned pregnancy (odds ratio [OR], 7.1; 95% confidence interval [CI], 2.4-20.7), smoking (OR, 0.2; 95% CI, 0.1-0.7), folic acid use during a former pregnancy (OR, 22.6; 95% CI, 5.5-92.8) and the number of previous children (per child OR, 0.5; 95% CI, 0.3-0.9) were predicting factors for the recommended use of folic acid; 89.9% of women were sufficiently knowledgeable to start to use folic acid before pregnancy.
The knowledge about folic acid has declined over recent years, and the use during the recommended period did not improve since the survey of 2005. Based on this survey, there is still room for improvement in the knowledge and actual use of folic acid before pregnancy. Attention to these aspects should focus on younger, low-educated women and should include information about family planning and contraceptives.
孕期及孕前补充叶酸可预防神经管缺陷。自1995年以来,已对孕妇进行了六项调查,以衡量她们对叶酸的了解和使用情况。本文将讨论2009年最新调查的结果,并与早期调查结果进行比较。
荷兰北部的孕妇在拜访助产士或妇科医生时被要求填写一份问卷。
在515名参与调查的女性中,87.0%在怀孕前就知道叶酸。在所有受访者中,51.6%报告在整个推荐期间使用了叶酸。多变量分析显示,计划妊娠(优势比[OR],7.1;95%置信区间[CI],2.4 - 20.7)、吸烟(OR,0.2;95% CI,0.1 - 0.7)、前次妊娠期间使用叶酸(OR,22.6;95% CI,5.5 - 92.8)以及既往子女数量(每个子女OR,0.5;95% CI,0.3 - 0.9)是推荐使用叶酸的预测因素;89.9%的女性具备足够的知识,能够在怀孕前开始使用叶酸。
近年来对叶酸的了解有所下降,自2005年调查以来,在推荐期间的使用情况并未改善。基于本次调查,孕前叶酸知识和实际使用情况仍有改进空间。对这些方面的关注应聚焦于年轻、低学历女性,并应包括计划生育和避孕方面的信息。