Cosmetic Ingredient Review, 1101 17th Street, NW, Suite 412, Washington, DC 20036, USA.
Int J Toxicol. 2011 Dec;30(6 Suppl):149S-227S. doi: 10.1177/1091581811428184.
Cyclomethicone (mixture) and the specific chain length cyclic siloxanes (n = 4-7) reviewed in this safety assessment are cyclic dimethyl polysiloxane compounds. These ingredients have the skin/hair conditioning agent function in common. Minimal percutaneous absorption was associated with these ingredients and the available data do not suggest skin irritation or sensitization potential. Also, it is not likely that dermal exposure to these ingredients from cosmetics would cause significant systemic exposure. The Cosmetic Ingredient Review Expert Panel concluded that these ingredients are safe in the present practices of use and concentration.
环甲基硅酮（混合物）和本次安全性评估中所审查的特定链长环状硅氧烷（n=4-7）均为环状二甲基聚硅氧烷化合物。这些成分具有共同的皮肤/毛发调理剂功能。这些成分具有最小的经皮吸收，现有数据表明其不会引起皮肤刺激或过敏。此外，化妆品中这些成分经皮肤暴露而导致显著的全身性暴露的可能性也不大。化妆品成分评估专家小组得出结论，这些成分在目前的使用和浓度下使用是安全的。
