Health Protection Agency North East, North East Health Protection Unit, Floor 2, Citygate, Gallowgate, Newcastle upon Tyne NE1 4WH, UK.
Arch Dis Child. 2012 Mar;97(3):248-9. doi: 10.1136/archdischild-2011-301074. Epub 2012 Jan 13.
A cluster of four confirmed cases of meningococcal disease was seen in the same nuclear family across a 15-week period. The cases were three siblings and a parent and all recovered well. The first case was confirmed by meningococcal PCR only but the subsequent three cases were due to indistinguishable strains of serogroup B (B:NT:P1.19-1,15-11). Contact tracing was initially undertaken and reviewed in detail after each subsequent case. Antibiotic prophylaxis was administered to close family contacts on three separate occasions, including switching of antibiotic agents, with good compliance. Subsequent investigation of the family has not revealed any obvious immunological problem and no further significant infections have been recognised. A cluster of meningococcal disease of this nature and timescale is highly unusual. Details of the cluster, investigation and implications for health protection practice are discussed.
在 15 周的时间内，同一核心家庭中出现了四例脑膜炎奈瑟菌病确诊病例。这些病例是三个兄弟姐妹和一个父母，所有人都康复良好。第一例病例仅通过脑膜炎奈瑟菌 PCR 确诊，但随后的三例病例是由于 B 群（B：NT：P1.19-1，15-11）不可区分的菌株引起的。在每个后续病例发生后，都进行了接触者追踪，并进行了详细审查。曾三次对密切接触者进行了抗生素预防治疗，包括更换抗生素药物，且依从性良好。对该家庭的后续调查并未发现任何明显的免疫问题，也未发现任何其他重大感染。这种性质和时间范围内的脑膜炎奈瑟菌病集群非常罕见。本文讨论了该集群的详细信息、调查结果以及对卫生保护实践的影响。
