Katz L H, Zelazny A, Scharf S, Hourvitz A, Asor N, Arbeli Y, Yust-Katz S, Smollan-Fredman G, Gdalevich M
Medical Corps, Israel Defense Forces, Aviv, Israel.
Clin Microbiol Infect. 2007 Sep;13(9):943-6. doi: 10.1111/j.1469-0691.2007.01767.x. Epub 2007 Jul 17.
The occurrence of three cases of meningococcal disease among children in a small community, two of whom attended the same day-care centre, prompted a programme of mass antibiotic prophylaxis. Nasopharyngeal and throat swabs were obtained on three occasions from all children registered at the day-care centre. Serogroup B Neisseria meningitidis was isolated from 13 of 61 children before prophylaxis, from three children after 2 weeks, and from 19 children after 3 months. Repetitive extragenic palindromic PCR analysis identified several meningococcal strains before treatment, one of which became predominant after 3 months. Mass antibiotic prophylaxis initially suppressed meningococcal carriage, but the carriage rate subsequently rebounded.
一个小社区的儿童中出现了3例脑膜炎球菌病病例，其中2名儿童在同一家日托中心，这促使开展了一项大规模抗生素预防计划。在日托中心登记的所有儿童被三次采集鼻咽和咽喉拭子。预防前，从61名儿童中的13名分离出B群脑膜炎奈瑟菌；2周后，从3名儿童中分离出该菌；3个月后，从19名儿童中分离出该菌。重复基因外回文PCR分析在治疗前鉴定出几种脑膜炎球菌菌株，其中一种在3个月后成为优势菌株。大规模抗生素预防最初抑制了脑膜炎球菌的携带，但携带率随后反弹。
