Transplantation-Oncology Infectious Diseases Program, Weill Cornell University Medical Center, 1300 York Avenue, New York, NY 10065, USA.
Clin Infect Dis. 2012 Feb;54 Suppl 1:S55-60. doi: 10.1093/cid/cir868.
Early diagnosis of invasive mucormycosis is important for timely therapeutic intervention, improved survival, and reduced morbidity. Given the importance of an accurate and rapid diagnosis of invasive mucormycosis to guide the timely initiation of amphotericin B and possible surgical intervention, a coordinated multidisciplinary approach of clinical assessment, diagnostic imaging, and laboratory assessment is necessary. Laboratory assessment for mucormycosis includes the conventional methods of direct examination and culture of tissue, respiratory secretions, bronchoalveolar lavage fluid, and other fluids. However, because conventional diagnostic tools are limited in their sensitivity, advanced molecular amplification systems, antigen detection assays, proteomic profiles, and metabolite detection may complement existing approaches to improve the rate of early diagnosis of invasive mucormycosis.
早期诊断侵袭性毛霉病对于及时进行治疗干预、提高生存率和降低发病率非常重要。鉴于准确快速诊断侵袭性毛霉病对于指导及时启动两性霉素 B 治疗和可能的手术干预非常重要，因此需要临床评估、诊断影像学和实验室评估的多学科协调方法。毛霉病的实验室评估包括组织、呼吸道分泌物、支气管肺泡灌洗液和其他体液的直接检查和培养等常规方法。然而，由于常规诊断工具的敏感性有限，因此高级分子扩增系统、抗原检测分析、蛋白质组学图谱和代谢物检测可能会补充现有方法，以提高侵袭性毛霉病的早期诊断率。
