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一名接受肝移植的成年患者并发播散性毛霉病感染性心内膜炎的管理挑战

Challenges in Management of Disseminated Mucormycotic Infection with Endocarditis in an Adult Patient Receiving Liver Transplantation.

作者信息

Wu Yue, Yu Xinyu, Zhang Yuntao, Liu Junfang, Chen Ying, Wang Rongrong, Zhang Wei

机构信息

Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.

Liver Transplant Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.

出版信息

Infect Drug Resist. 2025 Sep 5;18:4711-4721. doi: 10.2147/IDR.S534279. eCollection 2025.

Abstract

Mucormycosis is a rare fungal infection. With the recent advancements in diagnostic technologies, including molecular diagnostic techniques, such as PCR and metagenomic next-generation sequencing, the detection rates of mucormycosis have increased. However, its mortality rates remain alarmingly high. Although post-liver transplantation mucormycosis cases are infrequently reported (less than 1%), their mortality rate ranges from 60% to 90%, while mucormycotic endocarditis is even rarer. This article summarizes the clinical manifestations of mucormycosis in a post-liver transplantation adult patient and reviews the existing literature on mucormycotic endocarditis, with the aim of outlining its clinical features, diagnostic challenges, and therapeutic strategies.

摘要

毛霉菌病是一种罕见的真菌感染。随着包括分子诊断技术(如PCR和宏基因组下一代测序)在内的诊断技术的最新进展,毛霉菌病的检出率有所提高。然而,其死亡率仍然高得惊人。尽管肝移植后毛霉菌病病例报告较少(不到1%),但其死亡率在60%至90%之间,而毛霉菌性心内膜炎甚至更为罕见。本文总结了一名肝移植后成年患者毛霉菌病的临床表现,并回顾了关于毛霉菌性心内膜炎的现有文献,旨在概述其临床特征、诊断挑战和治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba2d/12420930/8a95264cd518/IDR-18-4711-g0001.jpg

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