Third Department of Pediatrics, Aristotle University, Hippokration Hospital, Thessaloniki, Greece.
Clin Infect Dis. 2012 Feb;54 Suppl 1:S61-6. doi: 10.1093/cid/cir869.
Mucormycosis is a devastating disease and can occur in patients with a variety of risk factors, the most important of which are immunosuppression, anatomic barrier breakdown, iron overload, and hyperglycemia/acidosis. Similarly to what occurs with Aspergillus, the host stimulates an innate immune response against the challenging sporangiospores and invading hyphae of Zygomycetes. This article discusses the host defense to different Zygomycetes, its augmentation, and its subsequent impact on the outcome of mucormycosis.
毛霉病是一种破坏性疾病，可发生于具有多种危险因素的患者，其中最重要的是免疫抑制、解剖屏障破坏、铁过载和高血糖/酸中毒。与曲霉菌相似，宿主对具有挑战性的接合孢子和侵入的毛霉菌丝会产生先天免疫反应。本文讨论了宿主对不同接合菌的防御、其增强以及对毛霉病结局的后续影响。
