Marcello M F, Nuciforo G, Romeo R, Di Dino G, Russo I, Russo A, Palumbo G, Schilirò G
Istituto di Anatomia Umana, Catania, Italy.
Cancer. 1990 Nov 15;66(10):2099-104. doi: 10.1002/1097-0142(19901115)66:10<2099::aid-cncr2820661010>3.0.co;2-3.
Ovarian biopsy specimens from ten girls (three postmenarcheal) who had undergone antiblastic treatment for acute lymphoblastic leukemia (ALL) and were in complete remission were examined by light microscope. The biopsy specimens from four of these patients (three postmenarcheal) were also observed by electron microscope. The structural and ultrastructural analysis showed a reduction in the number of follicles which were otherwise normal. No follicles were found in the thin sections from two of the three postmenarcheal girls, whereas normal follicles were observed in the third. The cortical stroma showed moderate to severe signs of fibrosis and changes of capillaries. All of these alterations were more evident in patients where ALL was diagnosed at an older age and this finding suggests that they are at a higher risk for low fertility or early menopause.
对10名曾接受过急性淋巴细胞白血病（ALL）抗胚细胞治疗且处于完全缓解期的女孩（3名初潮后）的卵巢活检标本进行了光学显微镜检查。其中4名患者（3名初潮后）的活检标本还进行了电子显微镜观察。结构和超微结构分析显示卵泡数量减少，不过卵泡本身正常。在3名初潮后女孩中的2名的薄片中未发现卵泡，而在第3名女孩中观察到正常卵泡。皮质基质显示出中度至重度的纤维化迹象和毛细血管变化。所有这些改变在ALL诊断时年龄较大的患者中更为明显，这一发现表明她们生育力低下或过早绝经的风险更高。
