Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
J Gynecol Oncol. 2011 Dec;22(4):292-4. doi: 10.3802/jgo.2011.22.4.292. Epub 2011 Dec 5.
Uterine carcinosarcomas are rare and highly aggressive tumors with a poor prognosis. Due to early metastasis and disease progression, it is known to be far more aggressive than matched grade 3 endometroid endometrial carcinomas. Five-year survival for stage IV is reported to be 10% and overall survival for stage IVB is expected to be very poor. The authors report one case after experiencing long-term survival (over 5 years) for stage IVB carcinosarcoma of uterus. Total abdominal hysterectomy and bilateral salpingo-oophorectomy was performed to 56 year old patient for uterine myoma. On pathology report, uterine carcinosarcoma was diagnosed and image studies were performed. With the impression of stage IVB uterine carcinosarcoma, 6 cycles of chemotherapy (ifosfamide and cisplatin) was conducted as adjuvant. Up to recently (over 5 years), she maintains good performance scale without evidence of tumor recurrence or disease progression.
子宫癌肉瘤是一种罕见且高度侵袭性的肿瘤，预后不良。由于早期转移和疾病进展，其侵袭性明显高于同等级别的子宫内膜样子宫内膜癌。据报道，IV 期的 5 年生存率为 10%，IVB 期的总生存率预计非常差。作者报告了一例 IVB 期子宫癌肉瘤的长期生存（超过 5 年）病例。对 56 岁的患者进行了全子宫切除术和双侧输卵管卵巢切除术，以治疗子宫肌瘤。病理报告诊断为子宫癌肉瘤，并进行了影像学研究。根据 IVB 期子宫癌肉瘤的印象，进行了 6 个周期的化疗（异环磷酰胺和顺铂）作为辅助治疗。直到最近（超过 5 年），她的表现良好，没有肿瘤复发或疾病进展的迹象。
