Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Diabet Med. 2012 Aug;29(8):1036-42. doi: 10.1111/j.1464-5491.2012.03576.x.
Serum androgen concentration is reported to be low in patients with Type 2 diabetes. There have been no studies comparing andropausal symptoms such as sleep disturbance, depression, erectile dysfunction and lower urinary tract symptoms simultaneously between men with Type 2 diabetes and subjects without diabetes.
We compared andropausal symptom scores such as the Pittsburgh Sleep Quality Index, the Self-Rating Depression Scale, the International Index of Erectile Function and the International Prostate Symptom Score in 296 men with Type 2 diabetes and in 267 subjects without diabetes. Furthermore, we evaluated relationships of andropausal symptom scores to various anthropometric factors and compared andropausal symptom scores according to diabetic complications in men with Type 2 diabetes.
Andropausal symptom scores such as the Pittsburgh Sleep Quality Index, the Self-Rating Depression Scale, the International Index of Erectile Function and the International Prostate Symptom Score were 4.2 ± 2.6 vs. 5.0 ± 3.3, P<0.01 by unpaired Student's t-test, 34.8 ± 8.2 vs. 38.4 ± 9.3, P<0.0001, 11.5 ± 6.4 vs. 9.9 ± 6.9, P<0.01 and 7.3 ± 6.7 vs. 9.0 ± 7.1, P<0.01 in subjects without diabetes and in patients with diabetes, respectively. The Pittsburgh Sleep Quality Index was higher in patients with neuropathy than without. The Self-Rating Depression Scale was higher in patients with advanced retinopathy. The International Index of Erectile Function was lower in patients with advanced retinopathy and nephropathy. The International Index of Erectile Function was lower and the International Prostate Symptom Score was higher in patients with cardiovascular disease than without.
Our data demonstrated that men with Type 2 diabetes have higher prevalence of andropausal symptoms, especially those with diabetic complications.
有报道称 2 型糖尿病患者的血清雄激素浓度较低。目前还没有研究同时比较 2 型糖尿病男性患者和无糖尿病患者的男性更年期症状，如睡眠障碍、抑郁、勃起功能障碍和下尿路症状。
我们比较了 296 例 2 型糖尿病男性患者和 267 例无糖尿病患者的男性更年期症状评分，如匹兹堡睡眠质量指数、自评抑郁量表、国际勃起功能指数和国际前列腺症状评分。此外，我们评估了男性更年期症状评分与各种人体测量因素的关系，并比较了 2 型糖尿病男性患者根据糖尿病并发症的男性更年期症状评分。
匹兹堡睡眠质量指数、自评抑郁量表、国际勃起功能指数和国际前列腺症状评分等男性更年期症状评分分别为 4.2±2.6 对 5.0±3.3，P<0.01 为非配对学生 t 检验，34.8±8.2 对 38.4±9.3，P<0.0001，11.5±6.4 对 9.9±6.9，P<0.01 和 7.3±6.7 对 9.0±7.1，P<0.01 在无糖尿病患者和糖尿病患者中。神经病患者的匹兹堡睡眠质量指数较高。晚期视网膜病变患者的自评抑郁量表评分较高。晚期视网膜病变和肾病患者的国际勃起功能指数较低。心血管疾病患者的国际勃起功能指数较低，国际前列腺症状评分较高。
我们的数据表明，2 型糖尿病男性患者出现男性更年期症状的患病率较高，尤其是那些有糖尿病并发症的患者。
