Goss P E, Bulbul M A
Division of Medical Oncology, Toronto General Hospital, Ontario, Canada.
Cancer. 1990 Nov 1;66(9):2044-6. doi: 10.1002/1097-0142(19901101)66:9<2044::aid-cncr2820660933>3.0.co;2-s.
Of a family of 13 siblings, four brothers have developed testicular neoplasms, one embryonal cell carcinoma and three testicular seminomas. A first cousin once removed on their mother's side of the family (fourth-degree relative) has developed an embryonal carcinoma. After treatment they are all alive and well. Their mother is a dizygous twin and one of ten siblings. Multiple other cancers have been diagnosed among her siblings and their offspring including breast carcinoma at age 30 years in monozygous twin nieces. Associated urogenital abnormalities, concordance of age, and discordance of pathology in the five males with testicular cancer is discussed. Further identification and reporting of this risk factor is encouraged.
在一个有13个兄弟姐妹的家庭中，4个兄弟患了睾丸肿瘤，其中1例为胚胎性癌，3例为睾丸精原细胞瘤。他们母亲家族的一个一代远亲（第四级亲属）患了胚胎性癌。经过治疗，他们都健在且情况良好。他们的母亲是异卵双胞胎之一，有10个兄弟姐妹。在她的兄弟姐妹及其后代中还诊断出多种其他癌症，包括一对同卵双胞胎侄女在30岁时患乳腺癌。讨论了5例睾丸癌男性患者相关的泌尿生殖系统异常、年龄一致性和病理不一致性。鼓励进一步识别和报告这一风险因素。
