Lynch H T, Katz D, Bogard P, Voorhees G J, Lynch J, Wagner C
Am J Med. 1985 May;78(5):891-6. doi: 10.1016/0002-9343(85)90302-x.
Familial testicular cancer is rare. This report describes a family with an unusual cancer spectrum that included the infantile form of embryonal carcinoma of the testis in the son of a cancer-free but putative obligate gene carrier mother, and the adult form of embryonal carcinoma in this women's maternal half-brother (their mutual mother had malignant melanoma and urinary bladder carcinoma). Hereditary syndrome designation remains elusive. Priority attention to biomarker research in families of this type for elucidation of cause and control is discussed.
家族性睾丸癌很罕见。本报告描述了一个具有不寻常癌症谱的家族，其中包括一位无癌症但被推测为必然基因携带者的母亲的儿子患有的婴儿型睾丸胚胎癌，以及该女性母系同父异母兄弟（他们的共同母亲患有恶性黑色素瘤和膀胱癌）患有的成人型胚胎癌。遗传性综合征的命名仍然不明确。讨论了优先关注此类家族中的生物标志物研究以阐明病因和进行控制。
