Department of Gastroenterology, Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, Charité Universitätsmedizin Berlin, Germany.
Saudi J Gastroenterol. 2012 Jan-Feb;18(1):55-8. doi: 10.4103/1319-3767.91734.
BACKGROUND/AIM: To investigate the geographic occurrence of mucosa-invading Fusobacteria in acute appendicitis.
Carnoy- and formalin-fixated appendices from Germany, Russia, and China were comparatively investigated. Bacteria were detected using fluorescent in situ hybridization. Cecal biopsies from patients with inflammatory bowel disease and other conditions were used as disease controls.
Fusobacteria represented mainly by Fusobacterium nucleatum were the major invasive component in bacterial infiltrates in acute appendicitis but were completely absent in controls. The occurrence of invasive Fusobacteria in Germany, Russia, and China was the same. The detection rate in Carnoy-fixated material was 70-71% and in formalin-fixated material was 30-36%.
Acute appendicitis is a polymicrobial infectious disease in which F. nucleatum and other Fusobacteria play a key role.
背景/目的：研究侵袭性梭杆菌在急性阑尾炎中的地理发生情况。
对来自德国、俄罗斯和中国的福尔马林和卡诺氏固定的阑尾进行了比较研究。使用荧光原位杂交法检测细菌。将来自炎症性肠病和其他疾病患者的盲肠活检用作疾病对照。
梭杆菌主要由具核梭杆菌组成，是急性阑尾炎细菌浸润的主要侵袭成分，但在对照组中完全不存在。侵袭性梭杆菌在德国、俄罗斯和中国的发生情况相同。卡诺氏固定材料的检出率为 70-71%，福尔马林固定材料的检出率为 30-36%。
急性阑尾炎是一种多微生物感染性疾病，其中具核梭杆菌和其他梭杆菌起着关键作用。
