Department of Respiratory Medicine, Næstved Hospital, 61 Ringstedgade, DK-4700, Næstved, Denmark.
Department of Respiratory and Internal Medicine, Zealand University Hospital Roskilde, Roskilde, Denmark.
Eur J Clin Microbiol Infect Dis. 2019 Jan;38(1):75-80. doi: 10.1007/s10096-018-3394-4. Epub 2018 Oct 29.
Fusobacterium species are components of the normal microbiota of the oral cavity, gastrointestinal tract, and female genital tract. They are increasingly recognized as causative agents of oral, laryngeal, and tonsillar infections. Several fusobacterial species are involved in infections, with F. necrophorum and F. nucleatum being the most commonly cultured subtypes. In this study, we aimed to investigate clinical and prognostic differences in terms of mortality and association with malignancy between F. necrophorum and F. nucleatum detected by culture and 16S rRNA gene sequencing. This is a systematic, comparative, retrospective, non-interventional study. Data were extracted from the Department of Clinical Microbiology, Region Zealand, Denmark: all patients with F. necrophorum or F. nucleatum detected by culture or 16S rRNA gene sequencing from 1st of January 2010 to 30th of June 2015 were included. In total, F. necrophorum was detected in samples from 75 patients, and F. nucleatum in samples from 68 patients (total: n = 143). Thirteen patients had a current cancer diagnosis at the time of fusobacterial sampling. Multivariate analyses revealed a significant association of "current cancer" with 30-day mortality. Fusobacterial subtype was not associated with mortality neither in overall nor in subgroups with or without current cancer. Despite differences in clinical disease pattern between F. necrophorum and F. nucleatum, mortality was unaffected by fusobacterial subtype. Mortality was significantly related to comorbidity, especially a current diagnosis of cancer. Our data highlights the current debate whether fusobacterial involvement in cancer may have disease-altering properties, rather than being opportunistic pathogens secondary to cancer disease.
梭杆菌属是口腔、胃肠道和女性生殖道正常微生物群的组成部分。它们越来越被认为是口腔、喉部和扁桃体感染的病原体。几种梭杆菌属参与感染，其中坏死梭杆菌和核梭杆菌是最常培养的亚型。在这项研究中，我们旨在研究通过培养和 16S rRNA 基因测序检测到的坏死梭杆菌和核梭杆菌在死亡率和与恶性肿瘤的相关性方面的临床和预后差异。这是一项系统的、比较的、回顾性的、非干预性研究。数据从丹麦西兰大区临床微生物学系提取：所有 2010 年 1 月 1 日至 2015 年 6 月 30 日通过培养或 16S rRNA 基因测序检测到坏死梭杆菌或核梭杆菌的患者均纳入研究。共从 75 例患者的样本中检测到坏死梭杆菌，从 68 例患者的样本中检测到核梭杆菌（总数：n=143）。在进行梭杆菌采样时，有 13 名患者有当前的癌症诊断。多变量分析显示，“当前癌症”与 30 天死亡率显著相关。梭杆菌亚型与死亡率之间没有相关性，无论是在总体患者中，还是在有或没有当前癌症的亚组中。尽管坏死梭杆菌和核梭杆菌的临床疾病模式存在差异，但死亡率不受梭杆菌亚型的影响。死亡率与合并症显著相关，特别是当前癌症的诊断。我们的数据强调了当前关于梭杆菌感染是否可能对癌症具有改变疾病性质的争论，而不是作为癌症疾病继发的机会性病原体。
