感觉反馈调节新生大鼠中 quipazine 诱导的踏步行为。
Sensory feedback modulates quipazine-induced stepping behavior in the newborn rat.
机构信息
Department of Psychology, Idaho State University, Pocatello, ID 83209-8112, United States.
出版信息
Behav Brain Res. 2012 Apr 1;229(1):257-64. doi: 10.1016/j.bbr.2012.01.006. Epub 2012 Jan 13.
Abstract
Research has shown that sensory feedback modulates locomotor behavior in intact as well as spinal adult animals. Here we examined if locomotor activity ("stepping") in newborn rats is influenced by cutaneous and proprioceptive feedback. One-day-old rats were treated with the serotonergic receptor agonist quipazine (3.0mg/kg) to induce air-stepping behavior or with saline (vehicle control). During stepping, a substrate/floor (elastic, stiff, or none) was placed beneath their limbs so that the feet could make plantar surface contact with a substrate. Pups treated with quipazine showed significantly more alternated fore- and hindlimb steps and plantar paw contact with the substrate, compared to pups treated with saline. Pups also made proportionately less contact with the stiff substrate versus the elastic substrate during stepping. Different types of movements made on the substrate (paw pushes, taps, swipes, and stances) were also characterized. These results indicate that sensory feedback modulates locomotor mechanisms and behavior in perinatal rats.
摘要
研究表明，感觉反馈调节完整的和脊髓成年动物的运动行为。在这里，我们研究了新生大鼠的运动活动（“踏步”）是否受到皮肤和本体感觉反馈的影响。一天大的大鼠用 5-羟色胺能受体激动剂 quipazine（3.0mg/kg）处理以诱导空气踏步行为，或用生理盐水（载体对照）处理。在踏步过程中，将底物/地板（弹性、刚性或无）置于它们的四肢下方，以便脚掌可以与底物进行足底表面接触。与用生理盐水处理的幼鼠相比，用 quipazine 处理的幼鼠表现出明显更多的交替前肢和后肢踏步以及足底与底物的接触。幼鼠在踏步过程中与刚性底物的接触比例也相对减少。还对在底物上进行的不同类型的运动（爪推、轻拍、轻扫和站立）进行了特征描述。这些结果表明，感觉反馈调节围产期大鼠的运动机制和行为。
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