Steinitz R, Iscovich J M, Katz L
Israel Cancer Registry, Ministry of Health, Jerusalem.
Cancer Detect Prev. 1990;14(5):547-53.
Differences in cancer incidence among various immigrant groups in Israel raised the question of persistence in their descendants. The methodological problems of identification of both parents and their origins, the choice of the denominator, and the long period of observation necessary for the rare childhood tumors have been examined. From 22-years data of the Israel Cancer Registry (ICR), three malignancies were chosen as examples: epithelial carcinoma of nasopharynx (31 cases), non-Hodgkin's lymphoma of nasopharynx (14 cases), and Ewing sarcoma (55 cases). The actual number of cases, in spite of the long period of incidence, is small and the computed significance must be accepted with reservation. There are two outstanding findings: the higher incidence in males as well as in females for nasopharynx carcinoma corresponds to that of their African-born parents; an increasing trend in the second 11-years period for Ewing sarcoma. Similar studies on leukemias, lymphomas, and others with a greater number of cases can be expected to have more reliable results. This survey relied on the majority of patients with immigrant parents, mostly of the same origin. In the following years, second and later generations of Israel-born and an increasing part of intermarriages will severely impede similar studies.
以色列不同移民群体之间癌症发病率的差异引发了其后代发病率是否持续存在的问题。研究探讨了确定父母双方及其祖籍、选择分母以及罕见儿童肿瘤所需的长期观察等方法学问题。根据以色列癌症登记处（ICR）22年的数据，选取了三种恶性肿瘤作为例子：鼻咽癌上皮癌（31例）、鼻咽非霍奇金淋巴瘤（14例）和尤因肉瘤（55例）。尽管发病时间较长，但实际病例数较少，计算出的显著性必须谨慎接受。有两个突出发现：鼻咽癌在男性和女性中的较高发病率与他们在非洲出生的父母的发病率相当；尤因肉瘤在第二个11年期间呈上升趋势。预计对白血病、淋巴瘤和其他病例数较多的疾病进行类似研究将得出更可靠的结果。这项调查主要基于父母为移民的大多数患者，他们大多来自同一祖籍。在接下来的几年里，第二代及以后在以色列出生的人以及越来越多的异族通婚情况将严重阻碍类似的研究。
