School of Social and Community Medicine, University of Bristol, Bristol, UK.
Int J Obes (Lond). 2012 Apr;36(4):559-66. doi: 10.1038/ijo.2011.272. Epub 2012 Jan 17.
To estimate lifetime cost effectiveness of lifestyle interventions to treat overweight and obese children, from the UK National Health Service perspective.
An adaptation of the National Heart Forum economic model to predict lifetime health service costs and outcomes of lifestyle interventions on obesity-related diseases.
Hospital or community-based weight-management programmes.
Hypothetical cohorts of overweight or obese children based on body mass data from the National Child Measurement Programme.
Lifestyle interventions that have been compared with no or minimal intervention in randomized controlled trials (RCTs).
Reduction in body mass index (BMI) standard deviation score (SDS), intervention resources/costs, lifetime treatment costs, obesity-related diseases and cost per life year gained.
Ten RCTs were identified by our search strategy. The median effect of interventions versus control from these 10 RCTs was a difference in BMI SDS of -0.13 at 12 months, but the range in effects among interventions was broad (0.04 to -0.60). Indicative costs per child of these interventions ranged from £108 to £662. For obese children aged 10-11 years, an intervention that resulted in a median reduction in BMI SDS at 12 months at a moderate cost of £400 increased life expectancy by 0.19 years and intervention costs were offset by subsequent undiscounted savings in treatment costs (net saving of £110 per child), though this saving did not emerge until the sixth or seventh decade of life. The discounted cost per life year gained was £13 589. Results were broadly similar for interventions aimed at children aged 4-5 years and which targeted both obese and overweight children. For more costly interventions, savings were less likely.
Interventions to treat childhood obesity are potentially cost effective although cost savings and health benefits may not appear until the sixth or seventh decade of life.
从英国国家医疗服务体系的角度评估治疗超重和肥胖儿童的生活方式干预措施的终生成本效益。
对国家心脏论坛经济模型进行改编,以预测生活方式干预措施对肥胖相关疾病的终生健康服务成本和结果。
医院或社区为基础的体重管理计划。
基于国家儿童测量计划的体重数据的超重或肥胖儿童的假设队列。
已在随机对照试验(RCT)中与无干预或最小干预进行比较的生活方式干预措施。
体重指数(BMI)标准差评分(SDS)降低、干预资源/成本、终生治疗成本、肥胖相关疾病和每获得 1 个生命年的成本。
通过我们的搜索策略确定了 10 项 RCT。这 10 项 RCT 中干预措施与对照组相比的中位数效应是 12 个月时 BMI SDS 的差异为-0.13,但干预措施之间的效果范围很广(0.04 至-0.60)。这些干预措施的每个孩子的指示性成本从 108 英镑到 662 英镑不等。对于 10-11 岁的肥胖儿童,一项在中等成本 400 英镑下导致 BMI SDS 在 12 个月时中位数降低的干预措施可使预期寿命延长 0.19 年,且干预成本被随后未贴现的治疗成本节省所抵消(每个孩子净节省 110 英镑),尽管这种节省直到生命的第六或第七个十年才出现。获得 1 个生命年的贴现成本为 13589 英镑。对于针对 4-5 岁儿童且针对肥胖和超重儿童的干预措施,结果大致相似。对于更昂贵的干预措施,节省的可能性较小。
治疗儿童肥胖的干预措施具有潜在的成本效益,尽管节省成本和健康效益可能要到生命的第六或第七个十年才会显现。