Loveman Emma, Al-Khudairy Lena, Johnson Rebecca E, Robertson Wendy, Colquitt Jill L, Mead Emma L, Ells Louisa J, Metzendorf Maria-Inti, Rees Karen
Effective Evidence LLP, 7 Bournemouth Road, Eastleigh, Hampshire, UK, SO53 3DA.
Cochrane Database Syst Rev. 2015 Dec 21;2015(12):CD012008. doi: 10.1002/14651858.CD012008.
Child and adolescent overweight and obesity have increased globally, and are associated with short- and long-term health consequences.
To assess the efficacy of diet, physical activity and behavioural interventions delivered to parents only for the treatment of overweight and obesity in children aged 5 to 11 years.
We performed a systematic literature search of databases including the Cochrane Library, MEDLINE, EMBASE, PsycINFO, CINAHL and LILACS as well trial registers. We checked references of identified trials and systematic reviews. We applied no language restrictions. The date of the last search was March 2015 for all databases.
We selected randomised controlled trials (RCTs) of diet, physical activity and behavioural interventions delivered to parents only for treating overweight or obesity in children aged 5 to 11 years.
Two review authors independently assessed trials for risk of bias and evaluated overall study quality using the GRADE instrument. Where necessary, we contacted authors for additional information.
We included 20 RCTs, including 3057 participants. The number of participants ranged per trial between 15 and 645. Follow-up ranged between 24 weeks and two years. Eighteen trials were parallel RCTs and two were cluster RCTs. Twelve RCTs had two comparisons and eight RCTs had three comparisons. The interventions varied widely; the duration, content, delivery and follow-up of the interventions were heterogeneous. The comparators also differed. This review categorised the comparisons into four groups: parent-only versus parent-child, parent-only versus waiting list controls, parent-only versus minimal contact interventions and parent-only versus other parent-only interventions.Trial quality was generally low with a large proportion of trials rated as high risk of bias on individual risk of bias criteria.In trials comparing a parent-only intervention with a parent-child intervention, the body mass index (BMI) z score change showed a mean difference (MD) at the longest follow-up period (10 to 24 months) of -0.04 (95% confidence interval (CI) -0.15 to 0.08); P = 0.56; 267 participants; 3 trials; low quality evidence. In trials comparing a parent-only intervention with a waiting list control, the BMI z score change in favour of the parent-only intervention at the longest follow-up period (10-12 months) had an MD of -0.10 (95% CI -0.19 to -0.01); P = 0.04; 136 participants; 2 trials; low quality evidence. BMI z score change of parent-only interventions when compared with minimal contact control interventions at the longest follow-up period (9 to 12 months) showed an MD of 0.01 (95% CI -0.07 to 0.09); P = 0.81; 165 participants; 1 trial; low quality evidence. There were few similarities between interventions and comparators across the included trials in the parent-only intervention versus other parent-only interventions and we did not pool these data. Generally, these trials did not show substantial differences between their respective parent-only groups on BMI outcomes.Other outcomes such as behavioural measures, parent-child relationships and health-related quality of life were reported inconsistently. Adverse effects of the interventions were generally not reported, two trials stated that there were no serious adverse effects. No trials reported on all-cause mortality, morbidity or socioeconomic effects.All results need to be interpreted cautiously because of their low quality, the heterogeneous interventions and comparators, and the high rates of non-completion.
AUTHORS' CONCLUSIONS: Parent-only interventions may be an effective treatment option for overweight or obese children aged 5 to 11 years when compared with waiting list controls. Parent-only interventions had similar effects compared with parent-child interventions and compared with those with minimal contact controls. However, the evidence is at present limited; some of the trials had a high risk of bias with loss to follow-up being a particular issue and there was a lack of evidence for several important outcomes. The systematic review has identified 10 ongoing trials that have a parent-only arm, which will contribute to future updates. These trials will improve the robustness of the analyses by type of comparator, and may permit subgroup analysis by intervention component and the setting. Trial reports should provide adequate details about the interventions to be replicated by others. There is a need to conduct and report cost-effectiveness analyses in future trials in order to establish whether parent-only interventions are more cost-effective than parent-child interventions.
全球儿童及青少年超重和肥胖问题有所增加,且与短期和长期健康后果相关。
评估仅针对父母开展的饮食、体育活动及行为干预对5至11岁儿童超重和肥胖的治疗效果。
我们对多个数据库进行了系统的文献检索,包括Cochrane图书馆、MEDLINE、EMBASE、PsycINFO、CINAHL和LILACS以及试验注册库。我们检查了已识别试验和系统评价的参考文献。我们未设语言限制。所有数据库的最后检索日期为2015年3月。
我们选择了仅针对父母开展的饮食、体育活动及行为干预的随机对照试验(RCT),用于治疗5至11岁儿童的超重或肥胖。
两位综述作者独立评估试验的偏倚风险,并使用GRADE工具评估总体研究质量。必要时,我们会联系作者获取更多信息。
我们纳入了20项RCT,共3057名参与者。每项试验的参与者数量在15至645之间。随访时间在24周至两年之间。18项试验为平行RCT,2项为整群RCT。12项RCT有两项比较,8项RCT有三项比较。干预措施差异很大;干预的持续时间、内容、实施方式和随访情况均不相同。对照也各不相同。本综述将比较分为四组:仅父母干预与亲子干预、仅父母干预与等待名单对照、仅父母干预与最小接触干预以及仅父母干预与其他仅父母干预。试验质量总体较低,很大一部分试验在个体偏倚风险标准上被评为高偏倚风险。在比较仅父母干预与亲子干预的试验中,体重指数(BMI)z评分变化在最长随访期(10至24个月)的平均差异(MD)为-0.04(95%置信区间(CI)-0.15至0.08);P = 0.56;267名参与者;3项试验;低质量证据。在比较仅父母干预与等待名单对照的试验中,在最长随访期(10 - 12个月)有利于仅父母干预的BMI z评分变化的MD为-0.10(95% CI -0.19至-0.01);P = 0.04;136名参与者;2项试验;低质量证据。在最长随访期(9至12个月)将仅父母干预与最小接触对照干预进行比较时,BMI z评分变化的MD为0.01(95% CI -0.07至0.09);P = 0.81;165名参与者;1项试验;低质量证据。在仅父母干预与其他仅父母干预的纳入试验中,干预措施和对照之间几乎没有相似之处,我们未汇总这些数据。总体而言,这些试验在BMI结果上各自的仅父母干预组之间未显示出实质性差异。其他结果,如行为测量、亲子关系和健康相关生活质量的报告不一致。干预的不良反应通常未报告,两项试验表明没有严重不良反应。没有试验报告全因死亡率、发病率或社会经济影响。由于质量低、干预措施和对照的异质性以及高失访率,所有结果都需要谨慎解释。
与等待名单对照相比,仅父母干预可能是治疗5至11岁超重或肥胖儿童的有效治疗选择。仅父母干预与亲子干预以及与最小接触对照干预相比具有相似效果。然而,目前证据有限;一些试验存在高偏倚风险,失访是一个特别问题,并且缺乏几个重要结果的证据。该系统评价确定了10项正在进行的试验,这些试验有仅父母干预组,这将有助于未来的更新。这些试验将提高按对照类型进行分析的稳健性,并可能允许按干预成分和环境进行亚组分析。试验报告应提供关于干预措施的足够详细信息,以便其他人能够重复。未来试验有必要进行并报告成本效益分析,以确定仅父母干预是否比亲子干预更具成本效益。