卢旺达基加利的异性恋夫妇中 HPV、HIV 和 HSV-2 的流行率和一致性。

Prevalence and concordance of HPV, HIV, and HSV-2 in heterosexual couples in Kigali, Rwanda.

机构信息

Department of Global Health, Academic Medical Center of the University of Amsterdam, The Netherlands.

出版信息

Sex Transm Dis. 2012 Feb;39(2):128-35. doi: 10.1097/OLQ.0b013e3182367c4c.

DOI:10.1097/OLQ.0b013e3182367c4c

PMID:22249302

Abstract

BACKGROUND

In the absence of prospectively collected transmission data, the transmission potential of a sexually transmissible infection (STI) can be estimated by its proxy of concordance in sexual partners. Here we report concordance data of 3 viral STIs: human papillomavirus (HPV), HIV, and herpes simplex virus type 2 (HSV-2) among heterosexual couples in Kigali, Rwanda.

METHODS

Cervical and penile HPV typing was performed among 166 community-sampled fertile couples in Kigali, Rwanda (median sampling interval 10 days (interquartile range: 5-36). HIV and HSV-2 serostatus, curable STIs, and sociobehavioral and clinical characteristics were also assessed.

RESULTS

Concordance rates for all 3 viral STIs were higher than expected by chance alone. Positive concordance among couples was 25% for HSV-2, 15.7% for any HPV, 8.4% for high-risk (HR)-HPV, and 6% for HIV. HR-HPV prevalence among women and men was 19.9% and 26.5%, respectively. Partner's HIV status was more strongly associated with HR-HPV detection in men (OR: 8.5; confidence interval: 2.9-24.6) than in women (OR: 1.9; confidence interval 0.5-6.7).

CONCLUSION

More than half of the couples were discordant for HIV, HPV, and/or HSV-2, indicating that prevention strategies directed to infected cases are important to protect their uninfected sexual partners.

摘要

背景

在缺乏前瞻性传播数据的情况下，可以通过性传播感染（STI）的一致性来估计其传播潜力。本研究报告了卢旺达基加利地区异性恋夫妇中 3 种病毒 STI（人乳头瘤病毒（HPV）、艾滋病毒和单纯疱疹病毒 2 型（HSV-2）的一致性数据。

方法

对卢旺达基加利的 166 对社区抽样的育龄夫妇进行了宫颈和阴茎 HPV 分型（中位数采样间隔为 10 天（四分位距：5-36））。还评估了 HIV 和 HSV-2 血清状况、可治愈的 STI、社会行为和临床特征。

结果

所有 3 种病毒 STI 的一致性率均高于单独偶然出现的预期。夫妇之间的阳性一致性为 HSV-2 为 25%、任何 HPV 为 15.7%、高危型（HR）-HPV 为 8.4%、HIV 为 6%。女性和男性的 HR-HPV 患病率分别为 19.9%和 26.5%。伴侣的 HIV 状况与男性中 HR-HPV 的检出更密切相关（OR：8.5；置信区间：2.9-24.6），而与女性中 HR-HPV 的检出关系较弱（OR：1.9；置信区间：0.5-6.7）。