Department of Global Health, Academic Medical Center of the University of Amsterdam, The Netherlands.
Sex Transm Dis. 2012 Feb;39(2):128-35. doi: 10.1097/OLQ.0b013e3182367c4c.
In the absence of prospectively collected transmission data, the transmission potential of a sexually transmissible infection (STI) can be estimated by its proxy of concordance in sexual partners. Here we report concordance data of 3 viral STIs: human papillomavirus (HPV), HIV, and herpes simplex virus type 2 (HSV-2) among heterosexual couples in Kigali, Rwanda.
Cervical and penile HPV typing was performed among 166 community-sampled fertile couples in Kigali, Rwanda (median sampling interval 10 days (interquartile range: 5-36). HIV and HSV-2 serostatus, curable STIs, and sociobehavioral and clinical characteristics were also assessed.
Concordance rates for all 3 viral STIs were higher than expected by chance alone. Positive concordance among couples was 25% for HSV-2, 15.7% for any HPV, 8.4% for high-risk (HR)-HPV, and 6% for HIV. HR-HPV prevalence among women and men was 19.9% and 26.5%, respectively. Partner's HIV status was more strongly associated with HR-HPV detection in men (OR: 8.5; confidence interval: 2.9-24.6) than in women (OR: 1.9; confidence interval 0.5-6.7).
More than half of the couples were discordant for HIV, HPV, and/or HSV-2, indicating that prevention strategies directed to infected cases are important to protect their uninfected sexual partners.
在缺乏前瞻性传播数据的情况下，可以通过性传播感染（STI）的一致性来估计其传播潜力。本研究报告了卢旺达基加利地区异性恋夫妇中 3 种病毒 STI（人乳头瘤病毒（HPV）、艾滋病毒和单纯疱疹病毒 2 型（HSV-2）的一致性数据。
对卢旺达基加利的 166 对社区抽样的育龄夫妇进行了宫颈和阴茎 HPV 分型（中位数采样间隔为 10 天（四分位距：5-36））。还评估了 HIV 和 HSV-2 血清状况、可治愈的 STI、社会行为和临床特征。
所有 3 种病毒 STI 的一致性率均高于单独偶然出现的预期。夫妇之间的阳性一致性为 HSV-2 为 25%、任何 HPV 为 15.7%、高危型（HR）-HPV 为 8.4%、HIV 为 6%。女性和男性的 HR-HPV 患病率分别为 19.9%和 26.5%。伴侣的 HIV 状况与男性中 HR-HPV 的检出更密切相关（OR：8.5；置信区间：2.9-24.6），而与女性中 HR-HPV 的检出关系较弱（OR：1.9；置信区间：0.5-6.7）。
超过一半的夫妇对 HIV、HPV 和/或 HSV-2 存在不一致，这表明针对感染病例的预防策略对于保护其未感染的性伴侣非常重要。
