Department of Pharmacology, Sahlgrenska Academy at the University of Gothenburg, SE-40530 Gothenburg, Sweden.
Department of Biomedical Laboratory Sciences, School of Health Sciences, College of Medicine and Health Sciences, University of Rwanda, Kigali P.O. Box 3286, Rwanda.
Viruses. 2023 Apr 19;15(4):1005. doi: 10.3390/v15041005.
The prevalence of human papillomavirus (HPV) infections in other anatomical sites besides the uterine cervix is unknown in East Africa. Here, we assessed the prevalence and concordance of HPVs in different anatomical sites in HIV concordant couples in Rwanda.
Fifty HIV-positive concordant male-female couples at the HIV clinic at the University Teaching Hospital of Kigali in Rwanda were interviewed, swabbed from the oral cavity (OC), oropharynx (OP), anal canal (AC), vagina (V), uterine cervix (UC) and penis. A pap smear test and a self-collected vaginal swab (Vself) were taken. Twelve high-risk (HR)-HPVs were analyzed.
HR-HPVs occurred in 10%/12% in OC, 10%/0% in OP and 2%/24% in AC ( = 0.002) in men and women, respectively. HR-HPVs occurred in 24% of UC, 32% of Vself, 30% of V and 24% of P samples. Only 22.2% of all HR-HPV infections were shared by both partners (κ -0.34 ± 0.11; = 0.004). The type-specific HR-HPV concordance was significant between male to female OC-OC (κ 0.56 ± 0.17), V-VSelf (κ 0.70 ± 0.10), UC-V (κ 0.54 ± 0.13), UC-Vself (κ 0.51 ± 0.13) and UC-female AC (κ 0.42 ± 0.15).
HPV infections are prevalent in HIV-positive couples in Rwanda but concordance within couples is low. Vaginal self-sampling for HPV is representative of cervical HPV status.
在东非，除了子宫颈以外，其他解剖部位的人类乳头瘤病毒（HPV）感染的流行情况尚不清楚。在这里，我们评估了卢旺达 HIV 阳性的夫妻中不同解剖部位 HPV 的流行情况和一致性。
在卢旺达基加利教学医院的 HIV 诊所，对 50 对 HIV 阳性的夫妻进行了访谈，并对他们的口腔（OC）、口咽（OP）、肛门（AC）、阴道（V）、子宫颈（UC）和阴茎进行了拭子取样。进行了巴氏涂片检查和自我采集的阴道拭子（Vself）。分析了 12 种高危型（HR）HPV。
男性和女性的 OC 中分别有 10%/12%、OP 中分别有 10%/0%、AC 中分别有 2%/24%发生 HR-HPV 感染（ = 0.002）。UC 中有 24%、Vself 中有 32%、V 中有 30%、P 样本中有 24%发生 HR-HPV 感染。只有 22.2%的 HR-HPV 感染是由夫妻双方共同携带的（κ=-0.34±0.11； =0.004）。OC-OC （κ0.56±0.17）、V-Vself （κ0.70±0.10）、UC-V （κ0.54±0.13）、UC-Vself （κ0.51±0.13）和 UC-女性 AC （κ0.42±0.15）之间的 HR-HPV 型别一致性具有统计学意义。
HPV 感染在卢旺达 HIV 阳性的夫妻中很普遍，但夫妻间的一致性较低。HPV 阴道自我采样可代表宫颈 HPV 状态。
