Department of Developmental, Psychotic, and Geriatric Psychiatry, Medical University of Gdansk, Srebrniki 1, 80-282, Gdańsk, Poland.
Neurol Sci. 2012 Dec;33(6):1459-61. doi: 10.1007/s10072-012-0938-8. Epub 2012 Jan 15.
We describe a 62-year-old female diagnosed with Alzheimer's disease, who had been treated with donepezil for approximately 1 year. When she developed a low-grade fever and digestive complaints, her family physician interpreted these symptoms as side effects of the drug and ordered donepezil to be discontinued. Not only was there no improvement of the somatic symptoms after discontinuation of donepezil, but there was also a worsening of the dementia symptoms, culminating in delirium. When donepezil was re-prescribed, the delirium resolved and the patient's mental state stabilized. The authors urge great caution in discontinuing treatment with acetylcholinesterase inhibitors such as donepezil.
我们描述了一位 62 岁的女性，她被诊断患有阿尔茨海默病，已经接受多奈哌齐治疗约 1 年。当她出现低热和消化不适时，她的家庭医生将这些症状解释为药物的副作用，并下令停用多奈哌齐。多奈哌齐停药后，不仅躯体症状没有改善，而且痴呆症状也恶化，最终出现意识模糊。当重新开出处方使用多奈哌齐时，意识模糊得到解决，患者的精神状态稳定。作者强烈呼吁在停用乙酰胆碱酯酶抑制剂（如多奈哌齐）时要非常谨慎。
