Vondrová H, Bartos V, Boucek P, Skibová J, Kalvodová B, Sosna T
Katedra neurologie, Institutu pro dalsí vzdĕlávání lékarů a farmaceutů, Praha.
Cas Lek Cesk. 1990 Sep 14;129(37):1161-5.
The authors investigated in 194 type I diabetics the incidence and severity of diabetic polyneuropathy in relation to other organ and vascular complications, incl. autonomous neuropathy. It was revealed that the increasing severity of polyneuropathy was significantly v séru (Cr equal to or less than 130-200 mumol/l); 4--Cr greater than 200 mumol/l; associated with severe stages of nephropathy and proliferative retinopathy with amaurosis. The concurrent presence of hypertension and polyneuropathy was surprising and striking--even in patients with the mildest grade 1 polyneuropathy hypertension was present in 10% and the incidence increased significantly with the increasing severity of polyneuropathy. Ischaemic heart disease and ischaemia of the lower extremities was significantly more frequent only in patients with grade 5 polyneuropathy. In patients with grade 4 and 5 neuropathy there was a 100% incidence of autonomous neuropathy in the cardiovascular sphere. The authors did not reveal significant differences between men and women as regards the relationship between the incidence of polyneuropathy and organ and vascular complications.
作者对194例I型糖尿病患者进行了研究，调查糖尿病多发性神经病变的发病率和严重程度与其他器官及血管并发症（包括自主神经病变）之间的关系。结果显示，多发性神经病变严重程度的增加与肾病的严重阶段以及伴有黑矇的增殖性视网膜病变显著相关（肌酐等于或低于130 - 200微摩尔/升；肌酐大于200微摩尔/升）。高血压与多发性神经病变同时存在的情况令人惊讶且显著——即使在最轻微的1级多发性神经病变患者中，高血压的发生率为10%，且随着多发性神经病变严重程度的增加，其发生率显著上升。仅在5级多发性神经病变患者中，缺血性心脏病和下肢缺血明显更为常见。在4级和5级神经病变患者中，心血管领域自主神经病变的发生率为100%。作者未发现多发性神经病变发病率与器官及血管并发症之间的关系在男性和女性之间存在显著差异。
