Stepchenkova E I, Kochenova O V, Zhuk A S, Andreĭchuk Iu V, Inge-Vechtomov S G
Gig Sanit. 2011 Nov-Dec(6):64-9.
Primary (spontaneous and externally induces) damages to genetic material frequently lead to heritable changes (gene mutations, chromosome aberrations and nondisjunction), which may cause cancer inherent and inborn diseases. It is suggested that primary damages may affect a phenotype until they are repaired or become mutations during inaccurate repair The alpha-test on the yeast Saccharomyces cerevisiae can answer the fundamental questions as the nature of primary damages that can be phenotypically manifested, their occurrence, conversion to each other and repair or conversion to heritable changes in genetic material.
遗传物质的原发性（自发和外部诱导）损伤常常导致可遗传的变化（基因突变、染色体畸变和不分离），这可能引发癌症及先天性和遗传性疾病。有人认为，原发性损伤可能会影响表型，除非它们得到修复，或者在不准确的修复过程中发生突变。对酿酒酵母进行的α测试可以回答一些基本问题，比如能够在表型上表现出来的原发性损伤的性质、它们的发生情况、相互转化以及修复或转化为遗传物质的可遗传变化的情况。
