Game J C
Division of Molecular and Cellular Biology, Lawrence Berkeley Laboratory, Berkeley, CA 94720.
Semin Cancer Biol. 1993 Apr;4(2):73-83.
The yeast Saccharomyces provides a powerful system for investigating the biological effects of ionizing radiation, and studies have identified double-strand breaks in DNA as probably of critical importance in determining lethality. These breaks are normally repaired by a recombinational mechanism, but in the absence of repair a single break may be lethal to the cell. Genetic and molecular analysis of the eight genes known as RAD50 to RAD57 has revealed much about recombinational repair. These genes are also of central importance in other processes including meiosis and may be of general significance in understanding radiation responses in eukaryotes.
酵母酿酒酵母为研究电离辐射的生物学效应提供了一个强大的系统，并且研究已经确定DNA中的双链断裂在决定致死性方面可能至关重要。这些断裂通常通过重组机制进行修复，但在没有修复的情况下，单个断裂可能对细胞是致命的。对称为RAD50至RAD57的八个基因的遗传和分子分析已经揭示了许多关于重组修复的信息。这些基因在包括减数分裂在内的其他过程中也至关重要，并且在理解真核生物的辐射反应方面可能具有普遍意义。
