Taudy M, Betka J
Otorinolaryngologická katedra FVL KU, Praha.
Cesk Otolaryngol. 1990 Sep;39(5):249-53.
The authors compare the effectiveness of three types of antibiotic prophylaxis (1. cephazoline, 2. combination ampicillin + oxacillin, 3. clindamycin) in a group of 32 patients with resection of oropharyngeal carcinomas and in a group of 47 laryngectomies with cervical block resection. The criterium is the incidence of postoperative infections, which called for a change of antibiotic treatment. The authors evaluates favourably prophylaxis with cephazoline and clindamycin; the incidence of complications is within the range of 17-30%. In ampicillin + oxacillin therapy unsatisfactory results with a 46% incidence of inflammatory complications were recorded. A gram-negative flora causes 45% infectious complications; the author also draws attention to the danger of anaerobic infections. In a primarily contaminated oropharyngeal area there is an incidence of postoperative infections by 30% higher in all types of evaluated prophylaxis, as compared with the laryngocervical area.
作者比较了三种抗生素预防措施（1. 头孢唑林，2. 氨苄西林 + 苯唑西林联合用药，3. 克林霉素）在32例口咽癌切除术患者组和47例喉切除术伴颈部淋巴结清扫术患者组中的有效性。评判标准是术后感染的发生率，这需要更换抗生素治疗。作者对头孢唑林和克林霉素的预防效果给予肯定评价；并发症发生率在17% - 30%范围内。在氨苄西林 + 苯唑西林治疗中，记录到不满意的结果，炎症并发症发生率为46%。革兰氏阴性菌引起45%的感染性并发症；作者还提请注意厌氧菌感染的危险。在口咽这个主要被污染的区域，与喉颈区域相比，在所有评估的预防类型中，术后感染发生率高出30%。
