SCID-hu Thy/Liv 小鼠中 C34 肽 HIV-1 融合抑制剂结合白蛋白的预先暴露预防。
Preexposure prophylaxis with albumin-conjugated C34 peptide HIV-1 fusion inhibitor in SCID-hu Thy/Liv mice.
机构信息
Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA.
出版信息
Antimicrob Agents Chemother. 2012 Apr;56(4):2162-5. doi: 10.1128/AAC.05015-11. Epub 2012 Jan 17.
Abstract
PC-1505 is a C34 peptide derived from the heptad repeat 2 region of HIV-1 gp41 conjugated to human serum albumin for sustained in vivo activity. One single preexposure dose of PC-1505 reduced viral RNA in HIV-1-infected SCID-hu Thy/Liv mice by 3.3 log₁₀ and protected T cells from virus-mediated depletion. In contrast, a single preexposure dose of Truvada reduced viral RNA by only 0.8 log₁₀ and was substantially less effective in preventing T cell depletion.
摘要
PC-1505 是一种源自 HIV-1 gp41 七肽重复 2 区的 C34 肽，与人血清白蛋白偶联以增强体内活性。单次暴露前给予 PC-1505 可使感染 HIV-1 的 SCID-hu Thy/Liv 小鼠的病毒 RNA 减少 3.3log₁₀，且可防止 T 细胞被病毒耗竭。相比之下，单次暴露前给予 Truvada 仅能使病毒 RNA 减少 0.8log₁₀，且在防止 T 细胞耗竭方面的效果明显较差。
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