Nagumo K, Okada N, Takagi M, Yamamoto H, Amagasa T, Fujibayashi T
Division of Clinical Laboratory, Faculty of Dentistry, Tokyo Medical and Dental University.
Bull Tokyo Med Dent Univ. 1990 Jun;37(1-2):27-34.
Squamous cell carcinoma (SCC) antigen is a tumor-associated antigen isolated from the squamous cell carcinoma of the uterine cervix. In order to estimate the usefulness of the SCC antigen in monitoring the clinical behaviors of oral squamous cell carcinomas, we analyzed clinicopathologically and immunohistochemically 54 cases of squamous cell carcinoma of the oral cavity. Elevated serum SCC antigen levels were detected in 23 (42.6%) out of 54 oral squamous cell carcinomas. The positive rate of serum SCC antigen levels was significantly higher in the patients with advanced clinical stages and poorly differentiated carcinoma. The serum levels declined rapidly after the surgical operation. It is considered that the serum SCC antigen levels could be useful in monitoring the extension, effectiveness of therapy, recurrence and metastases of the oral squamous cell carcinomas. Immunohistochemically, strong staining was seen in the cytoplasm of the well-differentiated carcinoma cells.
鳞状细胞癌（SCC）抗原是一种从子宫颈鳞状细胞癌中分离出的肿瘤相关抗原。为了评估SCC抗原在监测口腔鳞状细胞癌临床行为方面的作用，我们对54例口腔鳞状细胞癌进行了临床病理和免疫组化分析。54例口腔鳞状细胞癌中有23例（42.6%）检测到血清SCC抗原水平升高。临床晚期和低分化癌患者血清SCC抗原水平的阳性率显著更高。手术后血清水平迅速下降。认为血清SCC抗原水平可用于监测口腔鳞状细胞癌的扩展、治疗效果、复发和转移。免疫组化显示，高分化癌细胞的细胞质中可见强染色。
