Gotschuli A, Anderhuber W, Danninger R, Habermann W
Klinische Abteilung für Allgemeine HNO, Hals-Nasen-Ohren-Univ.-Klinik Graz.
Laryngorhinootologie. 1998 Mar;77(3):165-7. doi: 10.1055/s-2007-996953.
In the early 1970s, progress in chemical analysis allowed the assessment of low concentration substances in blood and other body fluids. These techniques led to development of hitherto unknown diagnostic facilities which were tested with respect to malignant tumors. In those days SCC-A was considered a promising substance for aiding in diagnosis and observation in patients with SCC.
This retrospective study investigates the correlation between tumor size and tumor progress and the SCC-A level in a group of 322 patients (male: n = 291, age 24-87 yrs, mean 56 yrs: female: n = 31, age 38-82 yrs, mean 70 yrs).
The diagnostic value of SCC-A turned out to be poor. In 78%, SCC-A levels were low and neither correlated with tumor size nor the presence of metastases. In follow-up the situation was even worse: A reliable correlation between SCC-A and the course of disease was found in 5.8% of patients only.
The SCC-A could neither reliably contribute to diagnosis nor to follow-up of patients with squamous cell carcinomas of the head and neck.
20世纪70年代初，化学分析技术的进步使得对血液和其他体液中低浓度物质的评估成为可能。这些技术催生了前所未有的诊断工具，并在恶性肿瘤患者中进行了测试。在那个时期，鳞状细胞癌相关抗原（SCC-A）被认为是一种有助于鳞状细胞癌（SCC）患者诊断和观察的有前景的物质。
这项回顾性研究调查了322例患者（男性：n = 291，年龄24 - 87岁，平均56岁；女性：n = 31，年龄38 - 82岁，平均70岁）的肿瘤大小、肿瘤进展与SCC-A水平之间的相关性。
SCC-A的诊断价值较差。78%的患者SCC-A水平较低，且与肿瘤大小和有无转移均无相关性。在随访中情况更糟：仅5.8%的患者中发现SCC-A与疾病进程之间存在可靠的相关性。
SCC-A对于头颈部鳞状细胞癌患者的诊断和随访均无法提供可靠依据。
