维生素 A 代谢与脂肪组织生物学。
Vitamin A metabolism and adipose tissue biology.
机构信息
Department of Medicine and the Institute of Human Nutrition, Columbia University, New York, NY 10032, USA.
出版信息
Nutrients. 2011 Jan;3(1):27-39. doi: 10.3390/nu3010027. Epub 2011 Jan 6.
Abstract
In recent years, the importance of vitamin A in adipose tissue biology, obesity and type II diabetes has become apparent. This review focuses on recent developments within the area of vitamin A and adipose tissue biology. Adipose tissue has an active vitamin A metabolism as it not only stores vitamin A but retinol is also converted to its active metabolite retinoic acid. Several mouse models point to a relationship between vitamin A metabolism and the development of adiposity. Similarly, in vitro studies provide new molecular mechanisms for the function of different forms of vitamin A and retinol- or retinoic acid-binding proteins in adipose tissue.
摘要
近年来，维生素 A 在脂肪组织生物学、肥胖症和 2 型糖尿病中的重要性变得越来越明显。本文重点介绍了维生素 A 与脂肪组织生物学领域的最新研究进展。脂肪组织具有活跃的维生素 A 代谢功能，因为它不仅储存维生素 A，还可将视黄醇转化为其活性代谢物视黄酸。几种小鼠模型表明，维生素 A 代谢与肥胖的发展之间存在关联。同样，体外研究也为不同形式的维生素 A 以及视黄醇或视黄酸结合蛋白在脂肪组织中的功能提供了新的分子机制。
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