夜间视力障碍史与中国人群糖尿病风险的关联：一项多中心、横断面研究。

Association between night blindness history and risk of diabetes in the Chinese population: a multi-center, cross sectional study.

机构信息

Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China.

Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, 225001, P.R. China.

出版信息

BMC Endocr Disord. 2024 Oct 29;24(1):231. doi: 10.1186/s12902-024-01721-2.

DOI:10.1186/s12902-024-01721-2

PMID:39472978

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11520579/

Abstract

AIMS

Night blindness (NB), an important manifestation of VA deficiency, may be associated with the odds of diabetes. The aim of this study was to explore the probable association between NB history and diabetes in Chinese community-dwelling adults.

METHODS

This multi-center, cross-sectional study enrolled a total of 5664 participants aged 18-82 years from eight sites in China. Information on demographics and medical history was collected using a standardized questionnaire. Diabetes was diagnosed based on the oral glucose tolerance test or a self-reported history. NB history was ascertained by a face-to-face interview with reference to the recommendation by the World Health Organization. Logistic regression analysis was used to evaluate the association between NB history and the odds of diabetes.

RESULTS

A total of 5049 participants were finally included, with 252 ascertained with NB history and 1076 with diabetes. The mean age of included participants was 52.9 years, and the percentage of participants with NB history was significantly higher in participants with diabetes than those without (7.0% vs. 4.5%). The multivariable adjusted odds ratio for diabetes was 1.41 (95% confidence interval 1.06, 1.89) in participants with NB history compared with those without. Furthermore, mediation analysis showed that obesity, as assessed by waist-height ratio, partially mediated the relationship between NB history and increased odds of diabetes.

CONCLUSIONS

The results suggest that NB history might be associated with increased odds of diabetes in Chinese community-dwelling adults.

摘要

目的

夜盲症（NB）是维生素 A 缺乏的一个重要表现，可能与糖尿病的发病风险相关。本研究旨在探讨中国社区成年人群中夜盲症史与糖尿病之间可能存在的关联。

方法

本多中心、横断面研究共纳入了来自中国 8 个地区的 5664 名年龄在 18-82 岁的参与者。使用标准化问卷收集了参与者的人口统计学和病史信息。糖尿病的诊断依据是口服葡萄糖耐量试验或自我报告的病史。夜盲症史通过面对面访谈，参照世界卫生组织的建议进行确定。采用 logistic 回归分析评估夜盲症史与糖尿病发病风险之间的关联。

结果

共纳入了 5049 名参与者，其中 252 名参与者有夜盲症史，1076 名参与者患有糖尿病。纳入参与者的平均年龄为 52.9 岁，患有糖尿病的参与者中夜盲症史的比例明显高于未患有糖尿病的参与者（7.0% vs. 4.5%）。与无夜盲症史的参与者相比，有夜盲症史的参与者患糖尿病的多变量调整比值比为 1.41（95%置信区间 1.06，1.89）。此外，中介分析表明，体重指数（waist-height ratio）评估的肥胖是夜盲症史与糖尿病发病风险增加之间关系的部分中介因素。