Buzurovic Ivan, Yu Yan, Podder Tarun K
Thomas Jefferson University, Medical Physics Division, Philadelphia, PA, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:2156-9. doi: 10.1109/IEMBS.2011.6090404.
Precise and accurate dose delivery is critically important in external beam radiation therapy. In many cases target-volumes are stationary, but the problem arises when the tumors move significantly due to cardiac and respiratory motions. This is a case for tumors in lung, esophagus, pancreas, liver, prostate, breast, and other organs in thoracic and abdominal regions. In the article we have described the Active Tracking and Dynamic Dose Delivery (ATDD) technique for real-time tumor motion compensation. In this approach, the robotic treatment table moves while delivering the radiation beam and compensates for breathing-induced tumor motion. Many parameters of the control system, such as patient mass or breathing pattern, are initially uncertain and may vary during the treatment. To solve these problems, feedforward adaptive control was adopted to minimize irradiation to healthy tissue and spare critical organs while ensuring prescribed radiation dose coverage to the target-volume.
精确给药在体外放射治疗中至关重要。在许多情况下，靶区是静止的，但当肿瘤因心脏和呼吸运动而显著移动时，问题就出现了。这适用于肺部、食管、胰腺、肝脏、前列腺、乳腺以及胸腹部其他器官的肿瘤。在本文中，我们描述了用于实时肿瘤运动补偿的主动跟踪和动态剂量输送（ATDD）技术。在这种方法中，机器人治疗床在输送辐射束时移动，以补偿呼吸引起的肿瘤运动。控制系统的许多参数，如患者体重或呼吸模式，最初是不确定的，并且在治疗过程中可能会发生变化。为了解决这些问题，采用前馈自适应控制，在确保对靶区规定的辐射剂量覆盖的同时，尽量减少对健康组织的照射并保护关键器官。
