Mahmud Mufti, Girardi Stefano, Maschietto Marta, Pasqualotto Elisabetta, Vassanelli Stefano
NeuroChip Laboratory, Department of Human Anatomy & Physiology, University of Padova, 35131 Padova, Italy.
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:2307-10. doi: 10.1109/IEMBS.2011.6090580.
The sensory information processing in the rodents is mainly done by whisking, through which they explore the environment, perform object localization, texture and shape discrimination very precisely. During whisking, microcircuits in the corresponding barrel columns get activated to segregate and integrate the tactile information through the information processing pathway. To primarily understand the whisking mechanism angular preferentiality determination is very important. In this work we propose an automated method to determine different events present in the local field potentials (LFPs), calculate latencies and amplitudes related to those events and use them along with the stimulation angle information to determine the angular preferentiality. The method is extensively tested on LFPs recorded from S1 barrel cortex of anesthetized rats using EOSFET (Electrolyte-Oxide-Semiconductor Field Effect Transistor) based neuronal probes.
啮齿动物的感觉信息处理主要通过触须摆动来完成，它们通过触须摆动来探索环境，非常精确地进行物体定位、纹理和形状辨别。在触须摆动过程中，相应桶状柱中的微电路被激活，以通过信息处理通路分离和整合触觉信息。为了初步理解触须摆动机制，确定角度偏好非常重要。在这项工作中，我们提出了一种自动化方法，用于确定局部场电位（LFP）中存在的不同事件，计算与这些事件相关的潜伏期和振幅，并将它们与刺激角度信息一起用于确定角度偏好。该方法在使用基于电解质-氧化物-半导体场效应晶体管（EOSFET）的神经元探针从麻醉大鼠的初级体感皮层（S1）桶状皮层记录的LFP上进行了广泛测试。
