Kottam Anil, Dubois John, McElligott Andrew, Henderson Kyle K
Department of Biomedical Engineering,University of Texas at Austin, Austin, TX 78712, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:2514-7. doi: 10.1109/IEMBS.2011.6090696.
The conductance catheter is a widely used tool to determine ventricular volumes in animal models. A tetra-polar catheter is inserted into the ventricle to measure instantaneous conductance, which is a combination of ventricular blood and surrounding myocardium. Various techniques have been used to separate the blood conductance signal from the combined measured signal [1], [2]. The blood conductance is then converted to volume using a linear relationship proposed by Baan [1] or an improved non linear relationship proposed by Wei [3]. We propose a novel approach that uses the combined blood-muscle signal to calculate volume, thereby eliminating the need to subtract out the muscle. In vivo experiments were performed in mice to validate this new approach and the results were compared with volumes obtained using ultrasound imaging.
电导导管是一种在动物模型中广泛用于测定心室容积的工具。将四极导管插入心室以测量瞬时电导，该电导是心室血液和周围心肌的组合。已经使用了各种技术来从组合测量信号中分离出血液电导信号[1,2]。然后使用Baan[1]提出的线性关系或Wei[3]提出的改进的非线性关系将血液电导转换为容积。我们提出了一种新颖的方法，该方法使用血液-肌肉组合信号来计算容积，从而无需减去肌肉信号。在小鼠中进行了体内实验以验证这种新方法，并将结果与使用超声成像获得的容积进行比较。
