Valenza G, Carboncini M C, Virgillito A, Creatini I, Bonfiglio L, Rossi B, Lanatà A, Scilingo E P
Department of Information Engineering and Interdepartmental Research Center E Piaggio, Faculty of Engineering, University of Pisa, Via G Caruso 16, 56122 Pisa, Italy.
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:3724-7. doi: 10.1109/IEMBS.2011.6090633.
The goal of this work is to investigate EEG (ElectroEncephaloGram) dynamics after drug intake in patients being in states of Disorders Of Consciousness (DOC) after brain injury. Four patients were involved in the study. All the patients exhibit cerebral lesions located in the same anatomical region. Two nonlinear indexes, such as Lempel-Ziv Complexity (LZC) and Approximate Entropy (ApEn), along with power spectra, were calculated for EEG signals gathered from electrodes placed on both injured and non-injured regions. Experimental results show that after drug administration the two nonlinear indexes calculated from EEG taken from injured regions increase (p < 0.001) while power spectra decrease or remain unchanged. These results do not pretend to draw conclusions about consciousness level either suggest promising therapeutical treatments, but represent only an experimental evidence about the change in the EEG complexity after drug administration.
这项工作的目标是研究脑损伤后处于意识障碍（DOC）状态的患者服药后的脑电图（EEG）动态变化。四名患者参与了该研究。所有患者的脑损伤均位于同一解剖区域。针对从受伤和未受伤区域放置的电极采集的脑电图信号，计算了两个非线性指标，如莱姆尔-齐夫复杂度（LZC）和近似熵（ApEn），以及功率谱。实验结果表明，给药后，从受伤区域采集的脑电图计算出的两个非线性指标增加（p < 0.001），而功率谱降低或保持不变。这些结果既无意得出关于意识水平的结论，也未暗示有前景的治疗方法，而仅代表给药后脑电图复杂度变化的实验证据。
