Bergman R, Friedman-Birnbaum R, Aviram M, Katz I, Kerner H, Brook J G
Department of Dermatology, Rambam Medical Center, Haifa, Israel.
Clin Exp Dermatol. 1990 Sep;15(5):372-5. doi: 10.1111/j.1365-2230.1990.tb02118.x.
A case of adult xanthogranulomatosis was investigated in depth for lipid abnormalities. The xanthogranulomatous lesion was shown to be composed primarily of cholesterol esters and triglycerides. Fasting plasma lipid levels and lipoprotein concentrations were within normal limits. Plasma lipoprotein electrophoresis and immunoelectrophoresis demonstrated normal high-density lipoprotein (HDL) and low-density lipoprotein mobilities. Polyacrylamide-gel isoelectric-focusing electrophoresis revealed increased levels of very-low-density apolipoprotein (apo) E, especially apo E-III. In the HDL fraction, apo-C-III and apo-E levels were both found to be slightly elevated. These findings might imply a causal relationship between the abnormal plasma apolipoprotein levels and the xanthogranulomatous disease.
对一例成人黄色肉芽肿病患者进行了深入的脂质异常调查。结果显示，黄色肉芽肿性病变主要由胆固醇酯和甘油三酯组成。空腹血浆脂质水平和脂蛋白浓度均在正常范围内。血浆脂蛋白电泳和免疫电泳显示高密度脂蛋白（HDL）和低密度脂蛋白迁移率正常。聚丙烯酰胺凝胶等电聚焦电泳显示极低密度载脂蛋白（apo）E水平升高，尤其是apo E-III。在HDL组分中，发现apo-C-III和apo-E水平均略有升高。这些发现可能意味着血浆载脂蛋白水平异常与黄色肉芽肿病之间存在因果关系。
