Markel A, Brook J G, Aviram M
Postgrad Med J. 1985 May;61(715):395-400. doi: 10.1136/pgmj.61.715.395.
Plasma lipid and high density lipoprotein (HDL) levels were studied in 20 normal, healthy, non-obese males while fasting (150 kcal/d with free intake of water) for 6 d in a hunger strike. Plasma triglyceride and cholesterol levels were increased by 18% after 6 d of fasting. HDL-cholesterol concentration was not significantly changed for 4 d, but decreased by 22% after 6 d. Platelet aggregation induced by adenosine diphosphate (ADP) or collagen after 6 d of fasting was in the normal range. In 3 subjects fasted for 9 d, a complete plasma lipoprotein analysis was done. Very low and low density lipoprotein (VLDL and LDL) levels were elevated, whereas HDL was reduced after 9 d of fasting. On isoelectric focusing analysis, a marked reduction in apolipoprotein (apo) E concentration in both VLDL and HDL was noted. Liver function tests showed a reduction in hepatic enzyme activity; and since apo E is of hepatic origin also, we suggest that long fasting inhibits liver function in normal subjects.
对20名正常、健康、非肥胖男性在绝食6天（每日摄入150千卡热量，可自由饮水）期间的血浆脂质和高密度脂蛋白（HDL）水平进行了研究。禁食6天后，血浆甘油三酯和胆固醇水平升高了18%。HDL胆固醇浓度在4天内无显著变化，但在6天后下降了22%。禁食6天后，由二磷酸腺苷（ADP）或胶原蛋白诱导的血小板聚集在正常范围内。对3名禁食9天的受试者进行了完整的血浆脂蛋白分析。禁食9天后，极低密度脂蛋白（VLDL）和低密度脂蛋白（LDL）水平升高，而HDL降低。在等电聚焦分析中，发现VLDL和HDL中的载脂蛋白（apo）E浓度均显著降低。肝功能测试显示肝酶活性降低；由于apo E也起源于肝脏，我们认为长期禁食会抑制正常受试者的肝功能。
