Pryce D W, King C M
Department of Dermatology, Royal Liverpool Hospital, UK.
Clin Exp Dermatol. 1990 Sep;15(5):384-6. doi: 10.1111/j.1365-2230.1990.tb02123.x.
Orofacial granulomatosis is a distinct clinical and pathological entity characterized by swelling of the lips and lower half of the face. Ulceration of the oral mucosa may also occur. Granulomas are seen histologically. Orofacial granulomatosis may occur in the Melkersson-Rosenthal syndrome, granulomatous cheilitis of Miescher, oral Crohn's disease, sarcoidosis and focal dental sepsis. The increased prevalence of atopy in patients with orofacial granulomatosis and the association with food intolerance suggests the possibility of a role for allergy in at least some cases.
口面部肉芽肿病是一种独特的临床和病理实体，其特征为嘴唇和面部下半部肿胀。口腔黏膜也可能发生溃疡。组织学上可见肉芽肿。口面部肉芽肿病可发生于梅尔克森 - 罗森塔尔综合征、米舍尔肉芽肿性唇炎、口腔克罗恩病、结节病和局灶性牙源性感染。口面部肉芽肿病患者特应性患病率增加以及与食物不耐受的关联提示，至少在某些病例中过敏可能起作用。
