用于远程医疗应用的便携式且经济高效的像素超分辨率片上显微镜。

Portable and cost-effective pixel super-resolution on-chip microscope for telemedicine applications.

作者信息

Bishara Waheb, Sikora Uzair, Mudanyali Onur, Su Ting-Wei, Yaglidere Oguzhan, Luckhart Shirley, Ozcan Aydogan

机构信息

Department of Electrical Engineering, University of California, Los Angeles 90095, USA.

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:8207-10. doi: 10.1109/IEMBS.2011.6092024.

DOI:10.1109/IEMBS.2011.6092024

PMID:22256247

Abstract

We report a field-portable lensless on-chip microscope with a lateral resolution of <1 μm and a large field-of-view of ~24 mm(2). This microscope is based on digital in-line holography and a pixel super-resolution algorithm to process multiple lensfree holograms and obtain a single high-resolution hologram. In its compact and cost-effective design, we utilize 23 light emitting diodes butt-coupled to 23 multi-mode optical fibers, and a simple optical filter, with no moving parts. Weighing only ~95 grams, we demonstrate the performance of this field-portable microscope by imaging various objects including human malaria parasites in thin blood smears.

摘要

我们报道了一种现场便携式无透镜片上显微镜，其横向分辨率小于1μm，视场约为24平方毫米。该显微镜基于数字同轴全息术和像素超分辨率算法，用于处理多个无透镜全息图并获得单个高分辨率全息图。在其紧凑且经济高效的设计中，我们使用了23个与23根多模光纤对接耦合的发光二极管以及一个简单的光学滤波器，且无移动部件。该显微镜仅重约95克，我们通过对包括薄血涂片上的人类疟原虫在内的各种物体进行成像，展示了这种现场便携式显微镜的性能。