Arad E, Flannery K, Wilson G A, O'Mara R E
Department of Radiology, Strong Memorial Hospital, University of Rochester Medical Center, New York 14642.
Clin Nucl Med. 1990 Oct;15(10):676-7.
Patients who have differentiated thyroid carcinoma and have undergone total thyroidectomy are treated with radioiodine for ablation of functional thyroid remnants. Administration of a single therapeutic dose in excess of 30 mCi of l-131 requires hospitalization. In an attempt to obviate the necessity for hospitalization, the prospective ablative dose was divided into two or three fractions given at weekly intervals on an ambulatory basis. To assess the effectiveness of this approach, this group of patients was compared to a cohort of hospitalized patients treated with a single dose. Ablation was achieved in 9 out of 12 patients treated in a fractionated manner (a 75% success rate), whereas in 16 out of 20 patients given a single dose the thyroid remnants were completely eradicated (an 80% success rate). That the use of split, smaller doses administered at weekly intervals on an ambulatory basis presents a reasonable alternative for ablation of postsurgical, residual-functioning thyroid tissue.
患有分化型甲状腺癌且已接受甲状腺全切术的患者，会接受放射性碘治疗以消融功能性甲状腺残余组织。给予超过30毫居里的单次治疗剂量的I-131需要住院。为了避免住院的必要性，将预期的消融剂量分成两到三份，每周间隔一次在门诊给予。为了评估这种方法的有效性，将这组患者与一组接受单次剂量治疗的住院患者进行了比较。以分次方式治疗的12名患者中有9名实现了消融（成功率75%），而接受单次剂量治疗的20名患者中有16名甲状腺残余组织被完全清除（成功率80%）。即每周间隔门诊给予分次的较小剂量，为消融术后残留有功能的甲状腺组织提供了一种合理的替代方法。
