Schümichen C, Bulczak-Schmidt M, Blattmann H, Pauli-Harnasch C
Nuklearmedizin. 1984 Oct;23(5):265-9.
The efficacy of high doses of radioiodine for total ablation of functional remnants left behind after total surgical thyroidectomy for thyroid cancer decreases with the number of treatments as well with the course of therapy. Most effective are 500 mCi of 131I administered in 5 fractions within 3 years. Up to 1000 mCi of 131I delivered within 5 years are still powerful but much less so. All further treatments with high doses of radioiodine are only of diagnostic value for detection of functional metastases with low radioiodine uptake. In about 45% of all patients even excessively high doses of radioiodine failed to ablate all functional residual thyroid tissue.
高剂量放射性碘对甲状腺癌全甲状腺切除术后残留功能组织进行完全消融的疗效，会随着治疗次数以及治疗疗程而降低。最有效的是在3年内分5次给予500毫居里的131I。在5年内给予高达1000毫居里的131I仍然有效，但效果要差得多。所有进一步使用高剂量放射性碘的治疗仅对检测低放射性碘摄取的功能性转移灶具有诊断价值。在所有患者中，约45%的患者即使使用过高剂量的放射性碘也未能消融所有功能性残留甲状腺组织。
