Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, Hunan 410078, China.
Pharmacogenomics. 2012 Jan;13(2):223-31. doi: 10.2217/pgs.11.137.
The safety and efficacy of candidate compounds are critical factors during the development of drugs, and most drugs have been withdrawn from the market owing to severe adverse reactions. Individuals/populations with different genetic backgrounds may show significant differences in drug metabolism and efficacy, which can sometimes manifest as severe adverse drug reactions. With an emphasis on the mechanisms underlying abnormal drug effects caused by genetic mutations, pharmacogenetic studies may enhance the safety and effectiveness of drug use, provide more comprehensive delineations of the scope of usage, and change the fates of drugs withdrawn from the market.
候选化合物的安全性和疗效是药物开发过程中的关键因素，大多数药物由于严重的不良反应而被撤出市场。具有不同遗传背景的个体/人群在药物代谢和疗效方面可能存在显著差异，有时表现为严重的药物不良反应。遗传突变导致药物异常作用的机制研究可以提高药物使用的安全性和有效性，更全面地描述药物的使用范围，并改变已撤出市场的药物的命运。
