Kalow Werner
Department of Pharmacology, University of Toronto, Medical Sciences Building, Toronto, M5S 1A8, Canada.
Expert Opin Pharmacother. 2005 Jul;6(8):1299-303. doi: 10.1517/14656566.6.8.1299.
This paper describes the functional roles of the closely related pharmacogenetic and pharmacogenomic sciences in medicine. Firstly, they provide means for a better understanding of the function of drugs, and particularly of the differences of drug action between individuals and also between racially categorised populations. Secondly, they are repeatedly used during the long process of new drug development; the developer needs several patient contacts. The development starts with target identification and ends with an official permission for medical use of a drug.
本文描述了密切相关的药物遗传学和药物基因组学在医学中的功能作用。首先，它们为更好地理解药物的功能提供了方法，尤其是个体之间以及不同种族人群之间药物作用的差异。其次，在新药研发的漫长过程中，它们被反复使用；研发人员需要与多名患者接触。研发从靶点识别开始，以药物获得医学使用的官方许可结束。
