Hercus Timothy R, Broughton Sophie E, Ekert Paul G, Ramshaw Hayley S, Perugini Michelle, Grimbaldeston Michele, Woodcock Joanna M, Thomas Daniel, Pitson Stuart, Hughes Timothy, D'Andrea Richard J, Parker Michael W, Lopez Angel F
Centre for Cancer Biology, SA Pathology, Adelaide, South Australia, Australia.
Growth Factors. 2012 Apr;30(2):63-75. doi: 10.3109/08977194.2011.649919. Epub 2012 Jan 18.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pluripotent cytokine produced by many cells in the body, which regulates normal and malignant hemopoiesis as well as innate and adaptive immunity. GM-CSF assembles and activates its heterodimeric receptor complex on the surface of myeloid cells, initiating multiple signaling pathways that control key functions such as cell survival, cell proliferation, and functional activation. Understanding the molecular composition of these pathways, the interaction of the various components as well as the kinetics and dose-dependent mechanics of receptor activation provides valuable insights into the function of GM-CSF as well as the related cytokines, interleukin-3 and interleukin-5. This knowledge provides opportunities for the development of new therapies to block the action of these cytokines in hematological malignancy and chronic inflammation.
粒细胞-巨噬细胞集落刺激因子（GM-CSF）是一种由体内多种细胞产生的多能细胞因子，它调节正常和恶性造血以及固有免疫和适应性免疫。GM-CSF在髓系细胞表面组装并激活其二聚体受体复合物，启动多个信号通路，这些信号通路控制着诸如细胞存活、细胞增殖和功能激活等关键功能。了解这些信号通路的分子组成、各种成分之间的相互作用以及受体激活的动力学和剂量依赖性机制，为深入了解GM-CSF以及相关细胞因子白细胞介素-3和白细胞介素-5的功能提供了有价值的见解。这些知识为开发新的疗法提供了机会，以阻断这些细胞因子在血液系统恶性肿瘤和慢性炎症中的作用。
