奥氮平诱导的小汗腺鳞状汗管化生。

Olanzapine-induced eccrine squamous syringometaplasia.

作者信息

Molina-Ruiz Ana María, Molina-Ruiz Rosa Maria, Zulueta Teresa, Barabash Román, Requena Luis

机构信息

Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

出版信息

Am J Dermatopathol. 2012 Jun;34(4):434-7. doi: 10.1097/DAD.0b013e31823812f1.

DOI:10.1097/DAD.0b013e31823812f1

PMID:22257902

Abstract

Eccrine squamous syringometaplasia is a histopathologic pattern that has mainly been described in patients receiving chemotherapy. Its association to nonchemotherapeutic agents is rare, with very few cases reported in the literature. We present the case of a 55-year-old patient with schizophrenia, who developed a skin eruption 5 weeks after initiating treatment with olanzapine. The histopathologic study revealed squamous syringometaplasia of the dermal eccrine ducts.

摘要

小汗腺鳞状化生是一种主要在接受化疗的患者中描述的组织病理学模式。它与非化疗药物的关联很少见，文献中报道的病例极少。我们报告一例55岁的精神分裂症患者，在开始使用奥氮平治疗5周后出现皮肤疹。组织病理学研究显示真皮小汗腺导管鳞状化生。