Chawla Nishtha, Kumar Saurabh, Balhara Yatan Pal Singh
Department of Psychiatry, National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical Sciences (AIIMS), New Delhi, India.
International Programme in Addiction Studies, King's College London, London, UK.
Indian J Psychol Med. 2017 Jul-Aug;39(4):537-538. doi: 10.4103/0253-7176.211763.
Adverse cutaneous reactions are known to occur with psychotropic medications, which may lead to poor drug compliance. As compared to other group of psychotropics, there is relatively scarce literature on olanzapine-induced skin eruptions. We present a case of a 39-year-old man diagnosed with first episode mania and alcohol dependence syndrome who was started on tablet olanzapine which leads to fixed drug eruptions. Exhaustive investigations were done, all of which came out within normal limits. A diagnosis of fixed drug eruptions was made by the dermatologist. The skin eruptions subsided after stopping olanzapine. It has, thus, been emphasized that clinicians should be aware of the potential cutaneous eruptions associated with olanzapine. Early detection of the same would lead to timely management and hence better compliance with the psychotropic treatment.
已知精神药物会引发不良皮肤反应,这可能导致药物依从性差。与其他精神药物组相比,关于奥氮平引起的皮肤疹的文献相对较少。我们报告一例39岁男性病例,该患者被诊断为首次发作的躁狂症和酒精依赖综合征,开始服用奥氮平片后出现固定性药疹。进行了详尽的检查,所有结果均在正常范围内。皮肤科医生做出了固定性药疹的诊断。停用奥氮平后皮肤疹消退。因此,强调临床医生应意识到与奥氮平相关的潜在皮肤疹。早期发现可导致及时处理,从而提高对精神药物治疗的依从性。