Baik Sang-hyun, Yoon Heung Sik, Kim Sang Eun, Kim Sang Hee
Department of Brain and Cognitive Engineering, Korea University, Seoul, Korea.
Neuroreport. 2012 Mar 7;23(4):251-4. doi: 10.1097/WNR.0b013e3283507533.
Extraversion is a core personality trait associated with individual differences in reward sensitivity and has been linked to the dopaminergic brain system. We investigated whether dopaminergic receptor availability in the striatum was directly associated with individual differences in extraversion using the high-affinity radiotracer [¹⁸F]fallypride and PET. Seventeen healthy male and female participants completed an [¹⁸F]fallypride PET scan at rest. Extraversion was assessed using the revised Eysenck Personality Questionnaire. Dopamine receptor availability in predefined striatal regions of interest was assessed as [¹⁸F]fallypride binding potential using a reference tissue model for [¹⁸F]fallypride. Both region of interest and voxel-based whole-brain analyses showed that extraversion was significantly correlated with dopaminergic receptor availability in the striatum bilaterally. This finding contributes to our understanding of the dopaminergic neural mechanisms underlying individual differences in extraversion.
外向性是一种与奖励敏感性个体差异相关的核心人格特质，并且与多巴胺能脑系统有关联。我们使用高亲和力放射性示踪剂[¹⁸F]法螺环丙哌啶和正电子发射断层扫描（PET）来研究纹状体中多巴胺能受体可用性是否与外向性的个体差异直接相关。17名健康的男性和女性参与者在静息状态下完成了一次[¹⁸F]法螺环丙哌啶PET扫描。使用修订后的艾森克人格问卷评估外向性。使用[¹⁸F]法螺环丙哌啶的参考组织模型，将预定义纹状体感兴趣区域中的多巴胺受体可用性评估为[¹⁸F]法螺环丙哌啶结合潜力。感兴趣区域分析和基于体素的全脑分析均显示，外向性与双侧纹状体中的多巴胺能受体可用性显著相关。这一发现有助于我们理解外向性个体差异背后的多巴胺能神经机制。
