Azevedo V F, Paiva E, Tosin T, Ferreira A, Ferreira A M, Fernandes M
Federal University of Paraná, Rua lamenha Lins 1110 ap 11a, Rebouças, Curitiba, Paraná, CEP 80250-020.
Reumatismo. 2011 Nov 9;63(3):171-4. doi: 10.4081/reumatismo.2011.171.
We present a rare case of splenic tuberculosis in a 42-year old man with long-standing ankylosing spondylitis treated with adalimumab. We review the association between antitumor necrosis factor therapy and splenic tuberculosis. Our case, like many other reported cases, illustrates that the index of suspicion of tuberculosis in patients treated with anti TNF therapies must be high and emphasizes that this rare infection may occur even with negative tuberculosis screening before the initiation of therapy.
我们报告了一例罕见的脾结核病例，患者为一名42岁男性，患有长期强直性脊柱炎，正在接受阿达木单抗治疗。我们回顾了抗肿瘤坏死因子治疗与脾结核之间的关联。我们的病例与许多其他已报道的病例一样，表明接受抗TNF治疗的患者对结核病的怀疑指数必须很高，并强调即使在治疗开始前结核病筛查为阴性，这种罕见的感染也可能发生。
