Department of Newborn Services, The Royal Women's Hospital, Melbourne, Australia.
Pediatr Res. 2012 Feb;71(2):210-4. doi: 10.1038/pr.2011.27. Epub 2011 Dec 21.
To better understand whether preeclampsia (PE) increases the risk of bronchopulmonary dysplasia (BPD).
Of 753 infants alive at 36 wks, 138 (18.3%) were exposed to PE. BPD was not significantly related to exposure to PE either before (odds ratio (OR) 0.73; 95% confidence interval (CI) 0.50, 1.06) or after adjustment for confounding variables (adjusted OR 1.14; 95% CI 0.71, 1.81). If infants were selected by gestational age alone, there was no association (OR 1.05; 95% CI 0.63, 1.75). In contrast, selecting by birth weight alone, PE was associated with a significant reduction in BPD (OR 0.61, 95% CI 0.41, 0.91). However, this effect disappeared after adjustment for confounding variables.
Conclusions were unchanged when data from other studies were included in a pooled analysis. PE does not significantly affect the risk of BPD in extremely preterm (EP) or extremely-low-birth-weight (ELBW) subjects.
We examined data on EP (<28 wks gestation) or ELBW (<1,000 g) infants live born in Victoria, Australia, in three eras: 1991-1992, 1997, and 2005. We compared the incidence of BPD (oxygen requirement at 36 wks' postmenstrual age) in the PE group (infants exposed to PE) with that in the remainder (nonexposed infants). We also contrasted results with comparable reported studies.
为了更好地了解先兆子痫（PE）是否会增加支气管肺发育不良（BPD）的风险。
在 36 周存活的 753 名婴儿中，有 138 名（18.3%）暴露于 PE。BPD 与 PE 的暴露无关，无论是在调整混杂变量之前（比值比（OR）0.73；95%置信区间（CI）0.50，1.06）还是之后（调整后的 OR 1.14；95%CI 0.71，1.81）。如果仅根据胎龄选择婴儿，则没有关联（OR 1.05；95%CI 0.63，1.75）。相反，仅根据出生体重选择婴儿时，PE 与 BPD 的显著减少相关（OR 0.61，95%CI 0.41，0.91）。但是，在调整混杂变量后，这种影响消失了。
纳入其他研究的数据进行汇总分析后，结论保持不变。PE 不会显著影响极早产（EP）或极低出生体重（ELBW）婴儿发生 BPD 的风险。
我们检查了澳大利亚维多利亚州在三个时期内活产的 EP（<28 周妊娠）或 ELBW（<1,000 克）婴儿的数据：1991-1992 年、1997 年和 2005 年。我们比较了 PE 组（暴露于 PE 的婴儿）和其余婴儿（未暴露的婴儿）的 BPD（出生后 36 周的氧需求）发生率。我们还将结果与可比的报告研究进行了对比。
